SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
نویسندگان
چکیده
منابع مشابه
SMAD4/DPC4 and Pancreatic Cancer Survival
Pancreatic cancer is the fourth leading cause of cancer deaths in both men and women in the United States, accounting for 30,000 deaths annually. It is a deadly disease with a 5-year survival of only 3–5% (1). The diagnosis of pancreatic adenocarcinoma is devastating to patients and their families, because the diagnosis is usually made at a late stage of disease that is not amenable to cancer c...
متن کاملAutophagy in Pancreatic Cancer
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more imp...
متن کاملPrognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis12
PURPOSE The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the association between SMAD4 expression and the outcome of pancreatic cancer patients by performing a meta-analysis. METHODS We systematically searched for relevant studies evaluating the relationship between SMAD4 ex...
متن کاملA novel SMAD4 gene mutation in seminoma germ cell tumors.
Transforming growth factor (TGF)-beta is known as an antiproliferative factor in the majority of mammalian cells, including stem germ cells. Lack of TGF-beta-induced growth inhibition has been associated with disruptions of TGF-beta receptors and SMADs. In the present study, we performed a mutational analysis of the TGF-beta signaling system, including TGF-beta receptor type I and type II and S...
متن کاملSMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
PURPOSE Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas. EXPERIMENTAL DESIGN We previously sequenced more than 750 million base pairs of DNA from 23,219 transcripts in a series of 24 adenocarcinomas of the pancrea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2018
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-17-3435